Bruce E Clurman Selected Research

Ligases (Synthetase)

1/2022	Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
1/2019	Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP.
1/2018	Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
10/2014	Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.
1/2013	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
6/2012	Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.
8/2007	FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
7/2005	Ras activity regulates cyclin E degradation by the Fbw7 pathway.
10/2004	A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Bruce E Clurman Research Topics

Disease

26	Neoplasms (Cancer) 01/2022 - 08/2002
12	Carcinogenesis 01/2022 - 06/2004
3	Lymphoma (Lymphomas) 08/2017 - 07/2007
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019 - 08/2007
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2019 - 08/2007
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2021
1	Squamous Cell Carcinoma of Head and Neck 11/2020
1	Merkel Cell Carcinoma 01/2019
1	T-Cell Lymphoma (Lymphoma, T Cell) 08/2017
1	Breast Neoplasms (Breast Cancer) 12/2014
1	Genomic Instability 05/2013
1	Disease Progression 06/2012
1	Hypoxia (Hypoxemia) 09/2011
1	Anemia 06/2008
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2007
1	Hyperplasia 08/2006
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2006
1	Chromosome Breakage 07/2005
1	Lung Neoplasms (Lung Cancer) 07/2005
1	Retinoblastoma (Glioblastoma, Retinal) 12/2004
1	Werner Syndrome (Werner's Syndrome) 07/2003

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2003
10	Cyclin EIBA 01/2019 - 10/2002
9	UbiquitinIBA 01/2022 - 10/2004
9	Ligases (Synthetase)IBA 01/2022 - 10/2004
4	CyclinsIBA 01/2019 - 10/2002
4	SKP Cullin F-Box Protein LigasesIBA 10/2014 - 06/2004
3	Oncogene Proteins (Oncogene Protein)IBA 11/2020 - 01/2018
3	Phosphotransferases (Kinase)IBA 11/2020 - 07/2005
3	MicroRNAs (MicroRNA)IBA 08/2017 - 01/2006
2	Notch ReceptorsIBA 01/2013 - 08/2007
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2008 - 08/2002
1	Arginine (L-Arginine)FDA Link 01/2022
1	Threonine (L-Threonine)FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	TubulinIBA 01/2021
1	adavosertibIBA 11/2020
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2019
1	Proto-Oncogene Proteins c-etsIBA 01/2019
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2019
1	TransposasesIBA 01/2019
1	F-Box-WD Repeat-Containing Protein 7IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 12/2014
1	Lapatinib (GW572016)FDA Link 12/2014
1	Calcibiotic Root Canal SealerIBA 06/2012
1	EnzymesIBA 10/2008
1	Indicators and Reagents (Reagents)IBA 12/2007
1	Transcription Factors (Transcription Factor)IBA 12/2007
1	Cyclin-Dependent Kinase Inhibitor p27IBA 12/2007
1	Gamma Secretase Inhibitors and ModulatorsIBA 08/2007
1	imidazole mustard (BIC)IBA 01/2006
1	Protein Isoforms (Isoforms)IBA 10/2005
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2004
1	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2004
1	Glycogen Synthase Kinase 3IBA 06/2004
1	RecQ HelicasesIBA 07/2003
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 10/2002
1	Cyclin DIBA 10/2002
1	Retinoblastoma ProteinIBA 10/2002

Therapy/Procedure

9	Therapeutics 01/2022 - 08/2003
1	Drug Therapy (Chemotherapy) 01/2021
1	Cell Transplantation 08/2007